Rift Valley fever virus noncoding regions of L, M and S segments regulate RNA synthesis
نویسندگان
چکیده
منابع مشابه
Rift Valley fever virus.
Vet Med Today: Zoonosis Update 883 R Valley fever virus is a mosquito-borne pathogen of livestock and humans that historically has been responsible for widespread and devastating outbreaks of severe disease throughout Africa and, more recently, the Arabian Peninsula. The virus was first isolated and RVF disease was initially characterized following the sudden deaths (over a 4-week period) of ap...
متن کامل1 1 Rift Valley fever virus MP - 12 vaccine is fully attenuated by a combination of 2 partial attenuations in the S - , M - and L - segments 3 4
4 Tetsuro Ikegami,1,2,3* Terence E. Hill,1 Jennifer K. Smith,1,4 Lihong Zhang,1,4 Terry L. 5 Juelich,1,4 Bin Gong, 1,3,4 Olga A.L. Slack, 1† Hoai J. Ly, 1 Nandadeva Lokugamage, 1 6 Alexander N. Freiberg,1,2,3,4 7 8 Department of Pathology, The Sealy Center for Vaccine Development, The Center for 9 Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, The 10 University of T...
متن کاملMolecular Epidemiology of Rift Valley Fever Virus
Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a p...
متن کاملRift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments.
UNLABELLED Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus), which has a tripartite negative-stranded RNA genome (consisting of the S, M, and L segments). Furth...
متن کاملMolecular Biology of Rift Valley Fever Virus
Rift Valley fever virus (RVFV) causes large outbreaks of acute febrile and often fatal illness among humans and domesticated animals in sub-saharan Africa and the Arabian peninsula. RVFV is a member of the family Bunyaviridae, genus Phlebovirus. Like all members of this large virus family, it contains a three-segmented genome of negative/ambisense strand RNA, packaged into viral nucleocapsid pr...
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ژورنال
عنوان ژورنال: Virology
سال: 2006
ISSN: 0042-6822
DOI: 10.1016/j.virol.2006.03.018